Vertical Diffusion Cells

Vertical Diffusion Cells

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VERTICAL DIFFUSION CELL.  

Creams, ointments, lotions and gels are topical drugs normally described as semisolid dosage forms. Unlike transdermal drug systems (see Note) which are applied to the skin for systemic effects (the drug penetrates the skin whereupon it is then absorbed into the blood stream), topical drugs are applied to the skin for local action principally to counter dermatological problems. Current USP thinking suggests two types of test to characterise semisolids, product quality tests (USP Chapter <3>) and product performance tests (the proposed USP Chapter <1724>).

The Vertical Diffusion Cell or Franz Cell is a simple, reproducible test for measuring the drug release from creams, ointments and gels. It is rapidly emerging as the apparatus of choice for the in vitro testing of drug release of topical semisolid dosage forms. The cell comprises two parts (a) the sample holder containing either 250 mg or 425 mg of the sample to be tested and (b) the reservoir of the diffusion cell itself containing the receptor medium. The two parts are separated by a membrane designed to act as a conduit for diffusion to take place and which serves to contain the test sample whilst ensuring that it remains in contact with the receptor medium. The receptor temperature is usually set to 32 degrees C to approximate normal skin conditions. Normally, no fewer than 6 samples are taken over a 6 hour period, say, 0.5, 1, 2, 4, 5 and 6 hours and analysed using HPLC or similar analytical technique.
PS59-104-120-Dosage Wafer, Strat-M, Double Thick w O-Ring, 15 mm x 3 mm

Dosage Wafer, Strat-M, Double Thick w/ O-Ring, 15 mm x 3 mm

PS59-104-120
PS59-104-140-Dosage Wafer, No-Leak, Double Thick w O-Ring, 15 mm x 3 mm

Dosage Wafer, No-Leak, Double Thick w/ O-Ring, 15 mm x 3 mm

PS59-104-140
No photo availablekopie

"Small" vertical diffusion cell, amber glass, 9 mm Orifice, cell only

PSVDC0904CO-AHR
No photo availablekopie

"Small" vertical diffusion cell, clear glass, 9 mm Orifice, cell only

PSVDC0904CO-HR
No photo availablekopie

Complete "small" vertical diffusion cell, Amber glass, 9 mm Orifice

PSVDC0904CP-AHR
PSVDC0904CP-HR-Complete small vertical diffusion cell, Clear glass, 9 mm Orifice

Complete "small" vertical diffusion cell, Clear glass, 9 mm Orifice

PSVDC0904CP-HR
PSVDC0904CT-HR-Threaded Cell Top 2, Clear Glass, 2ml volume suited for 4ml cell

Threaded Cell Top, Clear Glass, 2ml volume suited for 4ml cell

PSVDC0904CT-HR
PSVDC1507CO-AHR

"Standard" vertical diffusion cell, amber glass, 15mm mm Orifice, cell only

PSVDC1507CO-AHR
PSVDC1507CO-HR

"Standard" vertical diffusion cell, clear glass, 15mm mm Orifice, cell only

PSVDC1507CO-HR
PSVDC1507CP-AHR

Complete "standard" vertical diffusion cell, Amber glass, 15 mm Orifice

PSVDC1507CP-AHR
PSVDC1507CP-HR

Complete "standard" vertical diffusion cell, Clear glass, 15 mm Orifice

PSVDC1507CP-HR
PSVDC1507CT-AHR

Threaded cell top, Amber Glass, 6ml volume suited for 7, 12 and 20ml cells

PSVDC1507CT-AHR
PSVDC1507CT-HR

Threaded Cell Top, Clear Glass, 6ml volume suited for 7, 12 and 20ml cell

PSVDC1507CT-HR
PSVDC0904CP-HR-Complete small vertical diffusion cell, Clear glass, 9 mm Orifice

Threaded Cell Top, Clear Glass, 2ml volume suited for 4ml cell

PSVDC1507CT-HR
No photo availablekopie

"Large" vertical diffusion cell,amber glass, 15 mm Orifice, cell only

PSVDC1512CO-AHR
PSVDC1512CO-HR

"Large" vertical diffusion cell, clear glass, 15 mm Orifice, cell only

PSVDC1512CO-HR
No photo availablekopie

Complete "large" vertical diffusion cell, Amber glass, 15 mm Orifice

PSVDC1512CP-AHR
No photo availablekopie

Complete "large" vertical diffusion cell, Clear glass, 15 mm Orifice

PSVDC1512CP-HR
No photo availablekopie

"Extra large" vertical diffusion cell, amberr glass, 15 mm Orifice, cell only

PSVDC1520CO-AHR
No photo availablekopie

"Extra large" vertical diffusion cell, clear glass, 9 mm Orifice, cell only

PSVDC1520CO-HR
No photo availablekopie

Complete "extra large" vertical diffusion cell, Amber glass, 15 mm Orifice

PSVDC1520CP-AHR
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